Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period

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Studies on the Relationship of Alloxan-diabetes

A reduction in the size and incidence of tumors has been shown to occur in alloxanized Wistar rats given injections intraperi@oneally of homogenates of the transplantable Novikoff hepatoma (9, 10). Salzberg and Griffin (@6)likewise demonstrated a reduction in the incidence of DAB-induced hepa tomas in alloxanized rats, and Vangerov and Mc Kee (80) have recently reported a diminution in the grow...

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Sodium and its relation to alloxan diabetes and glutathione.

An investigation into the effect of sodium on alloxan diabetes was prompted by the following observations. The beneficial effect of sodium chloride for diabetic persons was demonstrated by McQuarrie et al. (1). They found that an increased intake of sodium chloride resulted in a decrease in the fasting level of blood sugar and in glycosuria. Sayers et al. (2) showed that the low glucose toleran...

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Hepatic proliferative response to insulin in severe alloxan diabetes.

Administration of insulin to severely diabetic rats leads to marked proliferation of liver cells. The activity of DNA polymerase and the incorporation of thymidine-3H into hepatic DNA in vivo are increased within 24 hr after insulin injections are started and reach peak levels between 48 and 72 hr. Total liver DNA increases approximately 70% during the period from 36 to 72 hr of insulin treatme...

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Quality is essential in diabetes disease registers.

O’Mullane and colleagues have reviewed the literature regarding the impact of diabetes registers on the process and outcomes of patient care. This review was conducted as part of a project aimed at establishing the feasibility of a national diabetes register in Ireland. A good starting point for assessing the usefulness of setting up a register is to review the existing evidence regarding effec...

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ژورنال

عنوان ژورنال: Asian Journal of Biochemistry

سال: 2007

ISSN: 1815-9923

DOI: 10.3923/ajb.2007.402.408